2016 年第 4 期 第 14 卷

紫杉醇致周围神经病变的诊治进展

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关键词：紫杉醇，周围神经病变，评估，治疗

• 摘要：
• 【摘要】化疗致周围神经病变是常见化疗相关毒副反应，患者因不能耐受神经病变所致的疼痛麻木中断治疗，影响预后。紫杉醇致周围神经病变是化疗最主要的剂量限制副作用。本文将对紫杉醇致周围神经病变的发生机制、评估方法以及治疗原则与经验思考予以阐述。
• Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect associated with chemotherapy. Patients cannot tolerate the pain and numbness caused by neuropathy, leading to treatment interruption, which also affect prognosis. Paclitaxel-Induced Peripheral Neuropathy (PIPN) is the main dose-limiting side effect of chemotherapy. This paper will discuss some ad-vances in pathogenesis, evaluation methods, treatment principles and experience for PIPN.