2016 年第 3 期 第 14 卷

非小细胞肺癌上皮间质转化与靶向药物耐药关系的研究进展

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关键词：非小细胞肺癌靶向治疗耐药上皮间质转化

• 摘要：
• 【摘要】肿瘤的上皮- 间质转化（epithelial-mesenchymal transitions，EMT）是指肿瘤在 各种因素作用下由上皮细胞转化为具有转移侵袭能力的间质细胞的过程。EMT与上皮细胞表型标志物（如E-钙黏蛋白）表达下调、间质细胞表型标志物（如波形蛋白）上调和相关基因表达及信号通路改变相关。EMT的发生能够促进肺癌转移、侵袭以及肿瘤干细胞特性获得,诱导肺癌细胞对靶向药物、化疗药物产生获得性耐药。因此，研究肺癌细胞EMT可以帮助人们在肿瘤抗耐药治疗中找到新的策略。本文旨在对EMT与非小细胞肺癌靶向治疗产生获得性耐药之间关系的最新研究进展作一综述。
• EMT (epithelial-mesenchymal transitions) refers to the progression in which tumor epithelial cells acquire mesenchymal features with high abilities of invasiveness and metastasis under various factors. EMT is characterized by down regulation of epithelial marker E-cadherin, upregulation of mesenchymal markers and regulation of expressions of related genes. EMT can promote the metastasis and invasiveness of lung cancer which acquiring a stem cell-like cell phenotype, and induce the acquired resistance of lung cancer to targeted therapy. It is also shown that the lung cancer cells, which display drug resistance, exhibit stem cell-like characteristics and EMT. The studies focusing on EMT may be helpful to find new strategies to reverse drug resistance in NSCLC. This article reviews the research progress on the relationship between EMT and acquired drug-resistance in NSCLC.