2017 年第 2 期 第 15 卷

胃癌患者新辅助化疗前后ki-67及β-catenin的表达及其相关性分析

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关键词：新辅助化疗ki-67β-catenin

• 摘要：
• 【摘要】目的 研究胃癌患者新辅助化疗前后ki-67及β-catenin的表达及其相关性分析。方法 选取2014年2月至2015年5月我院接诊的100例胃癌患者作为本次研究对象。给予胃癌患者新辅助化疗，观察ki-67和β-catenin不同表达情况的患者的预后情况，并对新辅助化疗的胃癌患者的预后情况进行Cox比例风险回归分析。结论 治疗前ki-67和β-catenin在不同性别，年龄，病程的患者中相比较无统计学差异；治疗前ki-67在肿瘤不同分期临床指标间的有统计学差异（P<0.05）。Ki-67阳性表达患者疗效较Ki-67阴性表达患者差（P<0.05），β-catenin阳性表达患者疗效也较β-catenin阴性表达患者差（P<0.05）。Cox比例风险回归分析结果显ki-67、β-catenin是影响胃癌患者预后的独立危险因素之一。结论 ki-67、β-catenin的表达变化可能作为指导胃癌新辅助化疗的重要指标之一，值得探讨。
• To study the expression and correlation of Ki-67 and β-catenin in patients with gastric cancer before and after neoadjuvant chemotherapy.Method 100 cases of patients with gastric cancer from February 2014 to May 2015 in our hospital were researched.Neoadjuvant chemotherapy for patients with gastric cancer,The prognosis of patients with different expression of Ki-67 and β-catenin was observed, and the prognosis of patients who treated with gastric cancer were analyzed by Cox proportional hazard analysis.Results Before treatment , Ki-67 and β-cateninin different gender, age, duration of the patients had no significant difference, andKi-67 in different pathological grading, staging, different hyperplasia degree clinical indicators had statistically significant difference (P < 0.05). And β-cateninin different pathological grading, staging had statistically significant difference (P < 0.05). The efficacy of Ki-67 positive patients was worse than Ki-67 negativ patients (P <0.05), The efficacy of β-catenin positive patients was worse than β-catenin negativ patients (P <0.05).Cox proportional hazards analysis showedKi-67 andβ-catenin were the independent risk factorswhich influenced the prognosis of patients with gastric cancer.conclusion Expression of Ki-67 and β-catenin can be used as an important index to guide the neoadjuvant chemotherapy of gastric cancer.Worth promoting.