2017 年第 1 期 第 15 卷

死亡相关蛋白激酶（DAPK）降解的研究

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关键词：死亡相关蛋白激酶（DAPK）泛素-蛋白酶体溶酶体

• 摘要：
• 【摘要】死亡相关蛋白激酶（DAPK）是钙离子/钙调素调节的丝氨酸/苏氨酸蛋白激酶，在细胞凋亡、自噬、增殖等过程中具有重要的作用，其功能的缺失与癌症、中风、炎症、阿尔茨海默氏病和动脉粥样硬化等疾病密切相关。DAPK蛋白降解受到泛素-蛋白酶体途径（UPS）和溶酶体途径的双重调控。全面深入的了解DAPK的蛋白降解，有利于对相关疾病的研究与治疗。
• Death Associated Protein Kinase 1（DAPK）is a serine/threonine kinase involved in the regulation of multiple cellular events such as apoptosis, autophagy and proliferation. Deregulation of DAPK is closely related to diseases such as cancer, stroke, inflammation, Alzheimer's disease and atherosclerosis. The degradation of DAPK is regulated by ubiquitin proteasome system（UPS）and lysosomal system. Understanding the regulation of DAPK degradation is conducive to the research on related diseases.