2017 年第 1 期 第 15 卷

白介素31和白介素33水平变化在子宫内膜癌患者中的临床意义

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关键词：白介素31白介素33子宫内膜癌临床意义

• 摘要：
• 【摘要】目的 探讨白介素31和白介素33水平变化在子宫内膜癌患者中的临床意义。方法 以本院2012年1月至2016年1月收治的92例子宫内膜癌为研究对象，以本院同期行健康体检的志愿者60例为对照组，采集所有研究对象静脉血，采用ELISA法测定IL-31和IL-33水平，免疫发光法测定肿瘤标志物（CEA、CA-125、CA19-9），分析比较两组IL-31和IL-33水平变化和对子宫内膜癌的诊断价值。结果 观察组IL-31水平（165.60±30.02）pg/ml显著高于对照组（77.20±20.85）pg/ml（t=17.516，P=0.000）；观察组IL-33水平（108.80±7.36）pg/ml显著高于对照组（74.28±21.90）pg/ml（t=9.246，P=0.000）。子宫内膜癌III和IV期患者IL-31水平高于I和II期患者（P＜0.05），子宫内膜癌临床分期越高或TNM分期越高者，其IL-33水平越高（P＜0.05）。ROC曲线分析显示，IL-31的诊断阈值为113.10 pg/ml（敏感性为92.68%，特异性为94.87%），AUC为0.973（95%CI：0.945-0.998，P＜0.01）；IL-33的诊断阈值为98.42 pg/ml（敏感性为88.64%，特异性为97.22%），AUC为0.929（95%CI：0.860-0.998，P＜0.01）。多指标联合诊断试验分析显示，IL-31联合IL-33对子宫内膜癌诊断的敏感性和特异性均显著高于CEA、CA-125和CA19-9。结论 IL-31和IL-33水平升高在子宫内膜癌的发生发展中发挥着重要作用，IL-31联合IL-33对子宫内膜癌具有重要的诊断价值。
• Objective To investigate the clinical significance of interleukin-31 and interleukin - 33 levels in patients with endometrial carcinoma. Methods 92 cases were collected in our hospital from January 2012 to January 2016 as the research group, and 60 cases of healthy volunteers in the same period as the control group, Fasting venous blood of all the subjects were collected, IL-31 and IL-33 levels were detected by ELISA and tumor markers (CEA, CA-125, CA19-9) were detected by immune chemiluminescence. IL-31 and IL-33 levels and diagnostic value for endometrial cancer were analyzed.Results IL-31 level in observation group (165.60 ± 30.02) pg/ml was significantly higher than the control group(77.20 ± 20.85) pg / ml (t=17.516, P= 0.000); IL-33 levels in the observation group (108.80 ± 7.36) pg/ml was significantly higher than the control group (74.28 ± 21.90) pg/ml (t= 9.246, P=0.000). IL-31 levels in III and IV of endometrial cancer patients was higher than I and II patients, Patients with endometrial cancer, clinical stage higher or higher TNM stage has the higher IL-33 levels (P<0.05). ROC curve analysis showed that IL-31 diagnostic threshold value of 113.10 pg/ml (sensitivity 92.68%, specificity 94.87%), AUC was 0.973 (95% CI: 0.945-0.998, P<0.01); IL-33 diagnostic threshold 98.42 pg/ml (sensitivity of 88.64% and a specificity of 97.22%), AUC was 0.929 (95% CI: 0.860-0.998, P<0.01). Multiple indexes diagnostic test analysis, diagnostic sensitivity and specificity of IL-31 combined with IL-33 endometrial cancer were significantly higher than CEA, CA-125 and CA19-9. Conclusion The increased IL-31 and IL-33 levels plays an important role in the development of endometrial cancer, IL-31 combined with IL-33 has important diagnostic value of endometrial cancer.