2015 年第 4 期 第 13 卷

MMP-11在乳腺浸润性导管癌肿瘤细胞中的表达与预后的相关性研究

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关键词：MMP-11预后乳腺癌远处转移

• 摘要：
• 【摘要】目的：研究MMP-11在乳腺浸润性导管肿瘤细胞的表达情况，探及MMP-11的表达与乳腺癌临床病理学指标及乳腺癌预后的相关性。 方法：本研究收集了2005-2008年总共285例诊断为浸润性导管癌的患者。应用免疫组织化学染色评估MMP-11在其肿瘤细胞中的表达情况，并收集患者的相关临床病理资料及随访信息。随后，评价MMP-11在乳腺癌中的表达情况及与临床病理学特征的相关性，并分析MMP-11的表达与乳腺癌预后的关系。 结果：MMP-11在肿瘤细胞中的表达与远处转移的出现显著相关（P<0.01）。MMP-11在肿瘤细胞中的表达和其他临床病理指标之间无相关性（P均>0.05）。单因素分析显示MMP-11在肿瘤细胞中的表达、组织学分级、脉管瘤栓、腋窝淋巴结情况、肿瘤分期及Ki67的表达均与无病生存期（DFS）和总生存率(OS)有相关性（P均<0.05），肿瘤大小与DFS有相关性（P<0.05）。多因素分析显示MMP-11在肿瘤细胞中的表达为DFS的独立影响因素。 结论：MMP-11在肿瘤细胞中的表达与乳腺癌预后的关系密切，对于预测预后意义重大。
• Objective: To investigate the correlation between the Matrix metalloproteinase-11 expression by tumor cells and clinicopathological features, and to evaluate whether MMP-11 expression was a predictor marker for prognosis in invasive ductal carcinoma of the breast . Methods: In this study, 285 invasive ductal carcinoma (IDC) patient samples were collected from 2005 to 2008. MMP-11 expression was examined in tumor cells by immunohistochemical staining, with clinical data and follow-up information from relevant patients collected. Subsequently, correlation analysis between IDC MMP-11 expression and clinicopathological features was performed, in addition to evaluating the relationship between MMP-11 expression and prognosis. Results: Tumor MMP-11 expression was significantly correlated with the presence of distant breast cancer metastases (P < 0.01). No significant correlation was found between tumor MMP-11 expression and other clinicopathological parameters (P > 0.05). Univariate analyses showed that tumor MMP-11 expression, tumor histological grade, vascular invasion, axillary lymph node metastasis, tumor stage and Ki67 expression were significantly associated with patient disease-free survival (DFS) and overall survival (OS) in IDC (P < 0.05), and tumor size were significantly associated with patient DFS (P < 0.05). Multivariate analysis showed that MMP-11 expression in tumor cells was independent factors affecting DFS, while it was not an independent factor affecting OS. Conclusion: MMP-11 expression in tumor cells was closely associated with IDC prognosis and significantly implicated as a potential predictive marker.