2015 年第 4 期 第 13 卷

结直肠癌可切除肝转移灶的术前化疗文献复习

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关键词：结直肠癌可切除肝转移灶术前化疗

• 摘要：
• 【摘要】结直肠癌是常见肿瘤之一，近一半的患者最终会发生肝转移，肝转移灶切除是唯一的治愈方法。对于评估为可切除肝转移灶，由于肝转移灶切除术后复发率高，患者生存期并未有显著延长，术前影像学难以发现的肝内微小转移灶成为局部复发的重要因素之一。术前化疗可以减少微小转移灶，增加R0切除率，减少术后复发风险。但是，是否所有评估为可切换除肝转移灶患者均可以从术前化疗中获益仍存在争议。本文复习相关文献，对目前有关结直肠癌可切除肝转移灶术前药物治疗的临床研究予以综述。
• Colorectal cancer is one of the most common cancer. Almost 50% patients will develop liver metastases. For patients with initially ressectable liver metastases, tumor resection does not significantly prolong overall survival because of the high recurrence rate. The most important reason is the micrometastases which imaging cannot find. Preoperative chemotherapy could shrink the micrometastases, improve R0 resection rate and reduce recurrence rate. However, whether all patients with initially resectable liver metastases could benefit from preoperative chemotherapy is still controversial. This article reviews clinical studies which focus on the preoperative chemotherapy of resectable colorectal cancer liver metastases.