2016 年第 7 期 第 14 卷

Hp感染与胃癌患者临床病理参数和生存状况的关系研究

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关键词：Hp感染胃癌病理参数生存状况

• 摘要：
• 【摘要】【摘要】目的：探究Hp感染与胃癌患者临床病理参数和生存状况的关系。方法：选择2010年1月至2012年6月在医院就诊的胃癌患者80例，根据患者是否发生Hp感染将患者分为感染组和未感染组，比较两组患者的临床病理参数和生存状况。结果：感染组患者的淋巴结转移N0期和N1期较多，而未感染组N1期、N2期人数较多，感染组患者Lauren分型中肠型比例较未感染组大，局部浸润T3、T4期比例较未感染组大，差异均有统计学意义（P<0.05），感染组患者的平均生存期明显低于对照组，且感染组患者中Hp感染量越大患者生存期越短，差异有统计学意义（P<0.05）；Cox回归分析显示，Hp感染、淋巴结转移、年龄、浸润深度均是影响胃癌患者生存状况的独立危险因素。结论：Hp感染与胃癌患者的临床参数有关，且Hp感染量越大患者的生存状况越差。
• Abstract Objective: To explore the relationship between Hp infection and clinical pathological parameters and survival in patients with gastric cancer. Methods: 80 patients with gastric cancer who were treated in hospital from June 2012 to January 2010, and were divided into two groups according to the patients with Hp infection. Are the number of more results: infection group of patients with lymph node metastasis N0 and N1, and uninfected group N1, N2, infection group with Lauren type midgut compared with uninfected group, local invasion T3, T4 compared with uninfected group, the differences were statistically significant (P < 0.05). The infection group were the average survival time was significantly lower than that of the control group and infection group in patients with HP infection, the more the amount of patients, the survival time is short, and the difference was statistically significant (P < 0.05); Cox regression analysis showed that HP infection, lymph node metastasis, age, depth of invasion of the gastric cancer patient survival status of independent risk factors. Conclusion: Hp infection is related to the clinical parameters of patients with gastric cancer, and the Hp infection is the worse the survival of patients with gastric cancer.