2016 年第 12 期 第 14 卷

D二聚体对伴肝脏疾病的胃癌患者临床预后的预测价值

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关键词：D二聚体胃肿瘤肝硬化预后回归分析

• 摘要：
• 【摘要】摘要：目的 探讨D二聚体对预测伴肝脏疾病的胃癌患者临床预后的价值。方法 纳入2000年1月至2011年1月我院收治的55例合并肝硬化的胃癌根治性手术患者，回顾性分析其临床资料，采用Kaplan-Meier法、Log-rank检验、COX模型分析患者预后的影响因素，重点明确D二聚体对患者预后的预测价值。结果 55例患者的1年生存率为78.2%、3年生存率43.6%、5年生存率18.2%。单因素分析显示D二聚体水平、年龄、Borrmann分型、病理组织分型、肿瘤大小、pTNM分期、肝功能Child-pugh分级对患者生存率有明显影响（P＜0.05），多因素分析提示D二聚体水平、pTNM分期、肝功能Child-pugh分级是预后的独立危险因素（P＜0.05）。D二聚体升高组与D二聚体正常组对比，pTNM分期及肝功能Child-pugh分级均有明显差异（P＜0.05）。结论 D二聚体对预测伴肝脏疾病的胃癌患者临床预后有一定价值。
• Abstract: Objective To investigate the value of D two polymer in predicting the prognosis of gastric cancer patients with liver disease. Method is incorporated into the 2000 January to 2011 January in our hospital were 55 cases with liver cirrhosis gastric cancer patients with radical surgery, retrospective analysis of the clinical data, using the Kaplan Meier method and log rank test, Cox model analysis of factors influencing the prognosis of the patients, a clear focus on D dimer of the predictive value of prognosis of the patients. Results the 1 year survival rate of 55 patients was 78.2%, the 3 year survival rate was 43.6%, and the 5 year survival rate was 18.2%. Single factor analysis showed D dimer levels, age, Borrmann typing, pathological type, tumor size, pTNM stage, child Pugh classification of liver function on survival rate had significant effect (P < 0.05). Multivariate analysis suggested that D-dimer level and pTNM stage, child Pugh classification of liver function is prognosis independent risk factors (P < 0.05). Compared with the normal group of D two, the pTNM stage and liver function were significantly different (P < 0.05) in the group with elevated D two. Conclusion D two polymer has a certain value in predicting the prognosis of gastric cancer patients with liver disease.