2016 年第 12 期 第 14 卷

年轻女性宫颈人乳头瘤病毒感染亚型与宫颈病变的调查

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关键词：人乳头瘤病毒（HPV）年轻女性基因分型

• 摘要：
• 【摘要】目的探讨年轻女性（年龄25-35岁）人乳头瘤病毒（HPV）感染亚型与宫颈病变的特点。方法采集2015年7月至2016年7月间1273例（年龄25-35岁间）我院门诊妇科患者宫颈上皮细胞标本，采用PCR-反向点杂交法对其进行21种基因分型的检测。结果（1）1273例年轻女性患者，HPV阳性有130例，检出率为10.2%；（2）单一型感染为115例，包括高危型感染105例，感染率为91%，低危型感染10例，感染率为8.7%；（3）最常见高危型是HPV16，共有35例，其次为HPV58，共2例；（4）HPV感染导致宫颈鳞状上皮高级别上皮内瘤变有10例，低级别上皮内瘤变有11例；（5）高危HPV阳性患者，宫颈活检证实为鳞状细胞癌的病例2例，均是HPV16感染。结论年轻女性HPV阳性检出率较高，以单一型感染和高危型感染为主，最常见的高危型是HPV16，其次为HPV58，HPV高危型感染导致宫颈鳞状上皮高级别上皮内瘤变有10例，低级别上皮内瘤变有11例，高危型HPV16引起宫颈鳞状细胞癌的有2例。
• [Abatract] Objective To investigate the characteristics of the subtypes of human papillomavirus(HPV) infected and cervical lesions in young women(aged 25-35years).Methods from July 2015 to July 2016 1273 cases (age 25-35 years) in our hospital outpatient gynecological patients of cervical epithelial cells were detected in 21 genotypes of PCR- using reverse dot blot method. Results (1) 1273 cases of young female patients, HPV positive in 130 cases, the detection rate was 10.2%. (2) single type infection was 115 cases, including 105 cases of high-risk infection, the infection rate was 91%, 10 cases of low risk of infection, the infection rate was 8.7%. (3) the most common high-risk HPV16, a total of 35 cases (4). The HPV infection in cervical squamous epithelium in high grade intraepithelial neoplasia in 10 cases, low grade intraepithelial neoplasia in 11 cases (5) HPV positive cervical biopsy is squamous cell carcinoma in 2 cases, were infected with HPV16. Conclusion young women HPV positive rate is higher, mainly infected by single type infection and high-risk, high-risk type is the most common HPV16, followed by HPV58, the high risk HPV infection cause cervical squamous epithelial high-grade intraepithelial neoplasia in 10 cases, low grade intraepithelial neoplasia in 11 cases, high risk caused by HPV16 cervical squamous cell carcinoma in 2 cases.