2016 年第 4 期 第 14 卷

新福菌素在眼眶及其附属器肿瘤治疗中的应用体会

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关键词：新福菌素眼眶及其附属物肿瘤围术期化疗

• 摘要：
• 【摘要】背景：新福菌素在淋巴瘤、黑色素瘤、鼻咽癌等多种恶性肿瘤的治疗中具有良好的疗效，淋巴瘤、黑色素瘤等肿瘤为眼眶及其附属器肿瘤的常见类型。目的：观察新福菌素在眼眶及其附属器肿瘤中的治疗效果和毒副作用。方法：收集2009年5月至2014年9月我院收治的眼眶及其附属器肿瘤患者，在手术前应用新福菌素，观察用药后不同类型肿瘤体积的变化、药物不良反应，随访12个月的肿瘤复发和患者生存情况。结果: 新福菌素对于黑色素瘤、非霍奇金淋巴瘤及上皮性转移瘤等肿瘤具有良好的治疗作用，可缩小肿瘤，使肿瘤边界更明确，在尽可能保证视力的同时确保完整切除肿瘤，术后肿瘤复发率低，患者生存率高，毒副作用较小。结论：新福菌素对于眼眶及附属器的常见肿瘤疗效好且副作用小，围手术期使用可确保肿瘤完整切除，减少复发，改善预后，值得临床推荐使用。 关键词
• BackgroundActinomycin has been proven to be effective in the treatment of a variety of tumors, such as lymphoma, melanoma and nasopharynx cancer. Lymphoma and melanoma are common types of the cancer of orbit and adnexa. Objectives To determine the efficacy and safety of actinomycinin the treatment of the cancer of orbit and adnexa.Methods85 patients who were diagnosed as orbit and adnexa cancer and received actinomycin injectionbefore surgery in our hospital in the duration between May, 2009 and September, 2014 were collected. We evaluated the change of tumor size, adverse reaction and tumor recurrence and patient survival situation afterfollowing-up for 12 months.ResultsActinomycinhada decent efficacy in the treatment of melanoma, non-hodgkin lymphoma, epithelium originated metastatic tumors in the way that it can reduce the size and sharpen the border of thetumors and thus provide a better chance of complete removal of the tumor without further damage to the vision or the function of the extraocular muscles. The tumor recurrence rate of patients with the combination use of actinomycinand surgerywas low and their survival ratewas high. The side effects of thisdrug were not severe.Conclusion: Actinomycinis efficientand safe in the treatment ofthe tumor of orbit and adnexa. Perioperative use of this drugis recommended to ensure complete tumor resection, reduce the recurrence rate and improve prognosis.