2015 年第 5 期 第 13 卷

HER2、COX-2在非小细胞肺癌中的表达意义

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关键词：人表皮生长因子受体2环氧化酶2非小细胞肺癌

• 摘要：
• 【摘要】摘要: 目的 探讨人表皮生长因子受体2（human epidermal growth factor receptor-2, HER2）和环氧化酶2（cyclooxygenase-2, COX-2）在非小细胞肺癌（non-small cell lung cancer, NSCLC）中的表达、其各自与临床特征之间的关系及二者在NSCLC中表达的相互关系。方法 采用免疫组化链霉菌抗生物素蛋白-过氧化物酶连结(streptavidin-peroxidase, SP)法检测72例NSCLC中HER2、COX-2的表达情况。结果 （1）72例NSCLC中，HER2、COX-2的阳性表达率分别为55.6%、65.3%；（2）HER2在NSCLC中的阳性表达与组织学类型、分化程度、肿块大小、淋巴结转移及临床分期相关（P<0.05），而与性别、年龄、吸烟、病变部位无关（P>0.05）；（3）COX-2 的阳性表达与年龄、组织学类型、肿块大小、淋巴结转移及临床分期相关（P<0.05），而与性别、吸烟、病变部位及分化程度无关（P>0.05）；（4）HER2、COX-2在NSCLC中的阳性表达呈正相关关系。结论 HER2、COX-2可以作为判断NSCLC恶性程度的生物学指标。
• Abstract: Objective To investigate the expression of HER2 and COX-2 in NSCLC and their associations with patients’ clinical characteristic. Methods The protein expression of HER2 and COX-2 were detected in 72 NSCLC by immunohistochemistry with streptavidin-peroxidase (SP) methods. Results (1) The positive rate of HER2 and COX-2 were 55.6% and 65.3% respectively. (2) The expression of HER2 were significantly correlated with histological type, histological grading, size of tumor, lymph node metastasis and clinical stage (P<0.05), while was not related with patients’ sex, age, tumor site and smoking status (P>0.05). (3) COX-2 expression were related to patients’ age, histological type, tumor mass, lymph node metastasis and clinical stage (P<0.05), but no significant correlation was found between COX-2 expression and patients’ sex, smoking status, tumor site and histological grading (P>0.05). (4) There was statistically positive correlation between expression of HER2 and COX-2. Conclusions Detection of HER2 and COX-2 can be used as indicators for judgment about prognosis in NSCLC.