2015 年第 2 期 第 13 卷

重楼抗肿瘤作用机制的研究进展

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关键词：重楼醇提物抗肿瘤作用机制

• 摘要：
• 【摘要】重楼为清热解毒类中药，作为重要组方成分广泛应用于抗肿瘤治疗。重楼抗肿瘤的有效成分主要为重楼总皂苷，醇提得出率较高。本文对重楼及其醇提物主要成分的体内外抗肿瘤作用机制进行整理，发现重楼抗肿瘤机制包括诱导凋亡、抑制增殖、抗血管生成、调节免疫及选择性作用于耐药肿瘤细胞。
• Rhizoma Paridis is among the detoxification class of the Chinese Traditional Medicine, and was used to treat cancer in many prescriptions. The most effective ingredients of the Rhizoma Paridis for cancer treatment are the rhizoma paridis saponins, and with a higher yield using alcohol based extraction method. The review focus on the anticancer effect and its mechanism for Rhizoma Paridis saponins in vitro and in vivo. Rhizoma Paridis play its anti-tumor effect by inducing tumor cell apoptosis，inhibiting tumor cell proliferation, suppressing the angiogenesis, regulating immune mechanisms and killing resistant cancer cell selectively.