2015 年第 2 期 第 13 卷

靶控麻醉对直肠癌根治术患者细胞免疫功能变化的影响研究

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关键词：靶控麻醉直肠癌根治术细胞免疫功能

• 摘要：
• 【摘要】目的：研究靶控麻醉与直肠癌根治术患者细胞免疫功能变化关系；方法：选择2012年8月——2014年10月在我院行直肠癌根治术治疗的患者68例，分为靶控麻醉组(34例)与对照组（34例），靶控麻醉组行靶控麻醉，对照组行全身麻醉；结果：靶控麻醉组麻醉成功、术毕、术后24h等时点肿瘤坏死因子-α、血清白细胞介素-6水平均较麻醉前升高（p＜0.05）；两组患者麻醉成功、术毕等时点的肿瘤坏死因子-α、血清白细胞介素-6水平均较麻醉前升高（p＜0.05）。靶控麻醉组麻醉成功、术毕等时点肿瘤坏死因子-α、血清白细胞介素-6水平均高于对照组（p＜0.05）。靶控麻醉组麻醉成功、术毕、术后24h等时点的CD3、CD4、CD8以及CD4/CD8均显著低于对照组（p＜0.05）；结论：与全身麻醉相比较，靶控麻醉能够显著抑制的患者的细胞免疫功能。
• Objective: To study the relationship between the target control anesthesia in radical operation of cell immune function of the patients with rectal cancer changes; methods: 68 patients in 2012 August -- 2014 October radical resection of rectal cancer treated in our hospital, were divided into target control anesthesia group (34 cases) and the control group (34 cases), Target control anesthesia group underwent target control anesthesia, the control group underwent general anesthesia.; results: Target control anesthesia anesthesia in the patients after successful, the end of operation, tumor necrosis factor - 24h point alpha, interleukin -6 in serum levels was significantly elevated compared with those before anesthesia (P < 0.05); control group of two groups of patients in the anesthesia and postoperative success at the tumor necrosis factor alpha, blood innocent interleukin -6 levels were significantly elevated compared with those before anesthesia (P < 0.05). Target control anesthesia group anesthesia success, postoperative time point such as tumor necrosis factor alpha, interleukin -6 in serum was significantly higher than those of the control group (P < 0.05). target control anesthesia group anesthesia success, after operation, postoperative 24h at CD3, CD4, CD8 and CD4/CD8 were significantly lower than those of the control group (P < 0.05); conclusion: Compared with general anesthesia, target control anesthesia can significantly inhibit the cellular immune function in patients.